【摘要】 目的观察原花青素对醋酸所致小鼠疼痛模型的影响。方法取小鼠72只,随机分为6组各12只,即原花青素高、中、低剂量组(分别灌胃给予原花青素120.0,24.0,4.8 mg.kg-1)和0.9%氯化钠溶液对照组(灌胃给予等量0.9%氯化钠溶液)、吗啡对照组(吗啡5 mg.kg-1灌胃)和阿司匹林对照组(阿司匹林500 mg.kg-1灌胃),均给药5 d。第5天所有小鼠腹腔注射0.6%醋酸溶液致痛,记录小鼠15 m in内扭体次数,比较各组扭体次数。结果原花青素高、中剂量组小鼠平均扭体次数分别为(4.33±2.43)和(6.50±2.91)次,均显著少于0.9%氯化钠溶液组(均P<0.05);原花青素低剂量组平均扭体次数(12.83±3.74)与0.9%氯化钠溶液组差异无显著性。原花青素各剂量组与阿司匹林组[(1.83±0.72)次]和吗啡组[(0.75±0.45)次]比较,扭体次数均显著较高(均P<0.05)。阿司匹林组和吗啡组平均扭体次数均较0.9%氯化钠溶液组少(均P<0.05)。原花青素高、中、低剂量组扭体反应的抑制率分别为74.53%,61.76%和26.46%。阿司匹林组和吗啡组扭体反应的抑制率分别为92.16%和95.59%。结论原花青素对醋酸所致小鼠疼痛模型有明显的镇痛作用,且镇痛作用与剂量呈量效关系。更多还原

【Abstract】 Objective To investigate effects of procyanidin on the murine pain pattern caused by acetic acid. Methods 72 mice were radomly divided into 6 groups : procyanidin groups(i.g.120.0,24.0 and 4.8 mg·kg-1,respectively),negative control group(i.g.NS),positive contrl group(i.g.5 mg·kg-1morphine) and aspirin group(i.g.500 mg·kg-1 aspirin).Mice were all treated for 5 days.On the fifth day,each mice was injected with 0.6% HAc to course pain model,and was recorded the number of writhing within 15 minutes. Results The numbers writhing in the groups of high and middle dose of procyanidin were(4.33±2.43) and(6.50±2.91),both were significant lower than those in the NS group(P<0.05,both);the low dose group showed no significant difference compared with NS group(P>0.05);Each Procyanidin group displayed higher numbers of writhing than those in aspirin and morphine group(P<0.05).Inhibiting rate for writhing in each Procyanidin groups was 74.53%,61.76%,26.46%,separately. Conclusion Procyanidin showed significantly analgesia effect on pain pattern caused by HAc,and which is dose-related.更多还原