【摘要】 β3肾上腺素受体分子结构与β1和β2受体有所不同;β3受体与心肌收缩活动有关;对心肌具有负性肌力作用,其作用可能是通过Gi蛋白、一氧化氮合成酶和环磷酸鸟苷介导等途径进行的;β3受体参与心衰的发病过程,心衰时,β1受体密度下调,而β3受体密度上调,受体表达增多。更多还原

【Abstract】 The molecular structure of β3-adrenoceptor is different from β1 and β2-adrenoceptor.β3-adrenoceptor has connection to the activities of myocardial contractility and negative isotropic effect on cardiac muscle.Its function is possibly carried on through Gi protein,nitric oxide synthetase and cyclic GMP.β3-adrenoceptor participates in the process of congestive heart failure.When the heart function fades,the density of β1-adrenoceptor declines,but the density of β3-adrenoceptor rises,the acceptor expression increases.更多还原