【摘要】 目的探讨肺表面活性物质(PS)治疗重症胎粪吸入综合征(MAS)的疗效。方法对16例重症MAS常规机械通气下,气管内滴入PS,比较用药前后的临床表现、血气分析结果、肺功能变化和并发症的发生。结果16例给药后发绀改善,吸气性呼吸困难减轻,2h内动脉血氧分压由5.6±1.0kPa升高至9.5±1.2kPa,动脉血二氧化碳分压由7.43±1.56kPa降至6.65±1.44kPa,氧合指数由8.15±1.4L至16.7±5.4L,14例MAS患儿治愈,2例自动出院。结论PS治疗重症MAS疗效肯定,值得临床推广。更多还原

【Abstract】 Objective To evaluate the effect of pulmonary surfactant(PS)on the treatment of meconium aspiration syndrome(MAS).Methods 16 severe MAS patients who was received routine mechanical ventilation,received pulmonary surfactant droping in through air hose.After the treatment,the clinical symptoms,blood gas analysis,change of lung function and complications were compared with before.Results After the therapy,cyanosis and inspiratory dyspnea of patients were improved.And 2-hour arterial partial pressure of oxygen was improved from 5.6±1.0kPa to 9.5±1.2kPa,arterial partial pressure of carbon dioxide was improved from 7.43±1.56kPa to 6.65±1.44kPa and oxygenation index was improved from 8.15±1.4 to 16.7±5.4.14 MAS patients were cured,2 patients discharged.Conclusions PS has well curative effect on the treatment of severe MAS.更多还原