【摘要】 目的:了解左旋咪唑不良反应的发生情况,为临床合理用药提供参考。方法:检索1984～2005年间国内外公开发表的有关左旋咪唑上市后研究文献,进行调查登记、数据整理、统计分析。结果:共获得文献98篇,其中国内72篇,国外26篇。共报道严重不良反应638例,其中国内602例,国外36例,包括脱髓鞘脑病586例,粒细胞缺乏症6例,皮疹4例,其他不良反应42例。结论:广大用药人群和临床医生务必高度重视LMS所引起严重的不良反应,提高警惕。更多还原

【Abstract】 Objective:To provide some reasonable reference for clinical medication by investigating the adverse reaction of levamisole.Method:The literatures published between 1984 and 2005 were reviewed by re-evaluating the post- marketing levamisole and its use and then analyzed.Result:A total of 98 literatures were got,including 76 domestic litera- tures and 26 overseas literatures.638 cases with adverse drug reaction (ADR) were reported,602 cases of which were do- mestic and 36 cases were overseas.Among all the 638 cases with ADR,586 cases were ill with demyelination disease,6 cases,agranulocytosis,4 cases,erythra and 42 cases presented some other adverse reactions.Conclusion:The most medi- cation crowd and clinicians must pay high attention to the severe adverse reaction of levamisole and raise vigilance when u- sing levamisole.更多还原