【摘要】 目的:观察中药复方制剂慢咽宁的药效学作用。方法:建立急性、亚急性、慢性炎症动物模型并分组给药,观察药物对引起慢性咽炎的常见细菌的抑制作用。结果:慢咽宁高剂量(12g生药/kg)能够抑制毛细血管通透性增高和足跖炎症肿胀;慢咽宁高、中剂量(8、4g生药/kg)能抑制炎症后期纤维组织增生和肉芽肿的形成;对大肠杆菌、金黄色葡萄球菌、肺炎链球菌、乙型链球菌和绿脓杆菌有不同程度的抑制作用,最小抑菌浓度(MIC)介于4～32mg/ml之间。结论:慢咽宁对急性、亚急性和慢性炎症都有不同程度的抑制作用。更多还原

【Abstract】 Objective:To explore the pharmacologic action of Manyangnin.Methods:Increasing of mice’s capillary permeability was caused to evaluate the influence of Manyangnin to acute inflammation.Swelling model of rat voix pedis was made to observe the inhibitory action of Manyangnin to sub-acute inflammation.Rats’ granuloma model was made to observe the effect of Manyangnin on chronic inflammation and detumescence.The bacteriostatic action of Manyangnin was evaluated in vitro.Results:Manyangnin,in the dosage of 12g/kg crud drug,can inhibit the increasing of capillary permeability and inflammatory swelling of voix pedis.In the dosage of 8、4g /kg crud drug,Manyangnin can repress fibroplasias and granuloma formation.Manyangnin presents bacteriostatic actions in vitro.Minimal inhibitory concentration(MIC)is from 4 to 32 mg/ml.Conclusion:Manyangnin presents inhibitory actions in different degree to acute,subacute and chronic inflammation.更多还原