【摘要】 目的:研究苏郁胶囊改善慢性应激抑郁行为与抗氧化作用。方法:将48只雄性大鼠分为正常组、模型组、苏郁胶囊高、中、低剂量组(22.8、11.4、5.7g/kg)及氯米帕明组(0.02g/kg)。采用长期不可预见中等强度应激结合孤养造成大鼠抑郁模型,测定各组大鼠体重增长克数,Open-field法和糖水消耗实验测定各组大鼠的行为变化;测定各组大鼠血清及大脑组织中超氧化物歧化酶(SOD)活性及丙二醛(MDA)含量。结果:苏郁胶囊可不同程度增加慢性应激大鼠的体重增长速度及糖水消耗量,改善大鼠行为缺损,同时提高血清及大脑中SOD活性,降低MDA含量。结论:苏郁胶囊能够改善慢性应激抑郁大鼠行为;其抗抑郁作用机制可能与清除体内过多自由基及抗脂质过氧化作用有关。更多还原

【Abstract】 AIM:To study the anti-oxidative properties of Suyu capsule that ameliorates the stress-induced chronic depressive-behavior in rats. METHODS: 48 male SD rats were separated randomly into 6 groups including the control group, the model group, three suyu capsule groups(the doses were 22.8,11.4,5.7 g/kg respectively)and Anafranil(0.02 g/kg). The model was established by separation and chronic unpredictable mild stimulation. Mensurating the increased weight,cane sugar water consumption and residence time,crossing score,rearing score by open-field;the activity of superoxide dismutase (SOD),the content of malondialdehyde(MDA) in serum and cerebra of rats were mensurated, too. RESULTS: Suyu capsule could improve the increased weight,cane sugar water consumption and improve the behavioral impairment obviously in chronic unpredictable stress depression rats;Suyu capsule also increased the activity of SOD and decrease the content of MDA in serum and cerebra of rats. CONCLUSION: Suyu capsule can ameliorate the behaviour of chronic unpredictable stressed rats. The inhibition of lipid peroxidation and the scavenging of free radical may account for the observed antidepressant effects.更多还原