【摘要】 目的观察复方鬼辣椒根口服液(以下简称复辣液)对小鼠长时间给药可能产生的毒性反应,为临床应用提供毒理学依据。方法取复辣液分别相当于人日用量的60倍、30倍、15倍,经90天小鼠灌胃给药,观察给药过程中、给药末期及停药恢复期动物的一般状况,主要血液学、血液生化学和脏器病理组织变化。结果各实验期动物一般状况良好,体重、脏器主要血液学指标、血液生化学指标与空白对照组基本一致,对性别、体重无影响,解剖主要脏器未见明显内眼可见的病理性改变。结论该品长期服用无明显毒性,停药后未见药物延迟性毒性反应。更多还原

【Abstract】 Objective To provide toxicological evidence for clinical use of Compound Wikstroemia indica Root Liquid (abbreviated as Wikstroemia Liquid) by examining the toxicity reaction of mice after receiving medicine for a long time.Methods The mice were intragastrically administered with Wikstroemia Liquid for 90 days continuous- ly.The doses of Wikstroemia Liquid were 60 times,30 times,15 times as human daily doses.The mice condition, major hematological indexes,blood biochemical and organ pathological tissues changes were observed during medicine administration,at the end of medicine treatment and resuscitation stage after medicine treatment.Results In ev- ery experimental stage,the mice presented a good condition,and the body weight and organ major hematological in- dexes,blood biochemical indexes were almost the same as blank control group.This medicine did not affect the mice sex ability and body weight;after being anatomized,the major organs were not found with pathological changes. Conclusion Wikstroemia Liquid has no toxicity for long-term use,and delayed drug adverse reaction dose not oc- cur after medicine stopping.更多还原