【摘要】 目的:探讨脑星形细胞肿瘤中多体素1H-MRS代谢物含量的变化及其与Ki-67间的相关性。方法:应用SiemensSonata 1.5T超导型MR成像系统对41例脑星形细胞肿瘤患者进行常规MR扫描及MRS检查,其中28例进行了Ki-67抗原指标的免疫组化染色。磁共振波谱分析采用四通道正交头部专用线圈3D-CSI序列扫描,比较分析不同级别星形细胞肿瘤间代谢物情况。用兔抗人Ki-67单克隆抗体测定肿瘤标本的Ki-67抗原标记指数。应用SPSS统计软件进行统计学相关性分析。结果:低级别组脑星形细胞肿瘤多体素?1H-MRS均表现为Cho峰不同程度增高和NAA峰不同程度的降低,5例出现Lac峰,无出现Lip峰。高级别组脑星形细胞肿瘤均表现为Cho峰明显增高,NAA不同程度的明显降低,21例出现Lac峰,11例出现Lip峰。高低级别肿瘤间Cho/Cr,Cho/NAA和Lac/Cr比值有统计学意义的差别。Cho/Cr、Cho/NAA比值与Ki-67指数间均存在明显的相关关系(其相关系数分别为0.640、0.694)。结论:多体素1H-MRS代谢物含量与Ki-67间有良好的相关性,磁共振波谱分析能够为星形细胞肿瘤治疗方案的制定提供更多信息。更多还原

【Abstract】 Objective:To explore the changes of multi-voxel 1 H-MRS metabolite contents and their relationships with Ki-67 in astrocytomas.Methods:41 cases astrocytomas were examined with MV-1H-MRS and routine MR. Ki-67 was detected in 28 patients with immunohistochemical method.All cases(high grade group 18 and low grade group 23) were histologically proved by operation.MRS images were acquired by using 3D-CSI sequence with four-way junction head coil.The correlation among metabolites of Multi-voxel MRS(Cho/Cr and Cho/NAA rate) with Ki-67 were analyzed by using SPSS statistics soft ware.Results:MR spectroscopy of low-grade and high-grade astrocytomas had demonstrated different levels of increasing in Cho peak,and the peaks of NAA were decreased in the different levels.Lac peak appeared in 5 cases of low grade and in 21 cases high grade astrocytomas,and 11 cases of high-grade astrocytomas appeared Lip peak.The difference in Cho/Cr,Cho/NAA and Lac/Cr rate of the two groups was significant statistically.Positive linear correlation was found obviously between Cho/Cr,Cho/NAA with Ki-67.The correlation coefficiencies were 0.684 and 0.783.Conclusion:MV 1H-MRS metabolite contents correlate well with Ki-67 in astrocytomas.MV 1H-MRS could provide more information in making treatment plan to the tumor.更多还原