【摘要】 目的:探讨放射性核素骨显像与血清前列腺特异性抗原(PSA)联合检测在前列腺癌骨转移诊断中的临床意义。方法:对130例前列腺癌患者的PSA检测结果及SPECT骨显像进行回顾性分析。结果:130例前列腺癌患者,骨显像诊断骨转移86例,阳性率为66.2%。在86例骨转移的患者中,发生脊椎转移77例,占77.9%,骨盆转移65例,占75.6%,肋骨转移42例,占48.8%,肩胛骨转移11例,占12.8%,胸骨转移7例,占8.1%,颅骨转移6例,占7%。脊椎和骨盆是前列腺癌骨转移主要涉及的部位。骨显像阳性组和骨显像阴性组PSA均值差异有显著性(P<0.01),PSA<20μg/L的前列腺癌患者发生骨转移的可能性小,PSA≥20μg/L的患者发生骨转移的可能性大。结论:PSA≥20μg/L的前列腺患者应行放射性核素骨显像检查。放射性核素全身骨显像与血清PSA浓度联合检测对于前列腺癌骨转移的临床诊断具有重要的指导意义。更多还原

【Abstract】 Objective:To probe the clinical significance of the combined detection of radionuclide bone imaging and plasma levels of prostate specific antigen(PSA) in patients with prostate cancer.Methods:To retrospectively analyze the levels of serum PSA and the findings of radionuclide bone imaging in 130 patients with prostate cancer.Results:Among 130 cases,86 cases with bone metastases were found by radionuclide bone imaging,with the positive rate 66.2%.In the 86 cases,the tumor location included 77(79.9%) in the spime,66(75.6%) in the pelvis,42(48.8%) in the rib,11(12.8%) in the scapnla,7(8.1%) in the sterntion,and 6(7%) in the skuel and the spine and pelvis were mainly involved sites for bone metastases of prostate cancer.The value of PSA between positive group and negative group had significant difference(P<0.01).Prostate cancer patients with PSA<20μg/L had low morbidity for bone metastases.While for patients with PSA≥20μg/L,the morbidity for bone metastases was high.Conclusion:Radionuclide bone imaging should be performed in prostate cancer patients with PSA≥20μg/L.The combined detection of radionuclide bone imaging and the serum PSA levels would play an important role in clinical diagnosis of bone metastases for patients with prostate cancer.更多还原