【摘要】 目的探讨非糖尿病的冠心病患者尿微量白蛋白(MAU)与冠脉病变程度的关系。方法对172例可疑冠心病的非糖尿患者进行冠状动脉造影检查并检测其尿白蛋白排泄率(UAER)。根据冠状动脉造影结果将患者分为对照组51例和冠心病组121例。根据病变血管的数量分为无血管病变组51例、单支病变组51例、双支病变组32例、三支及以上病变组38例,对比各组间UAER和MAU阳性率之间的差异。结果冠心病组男性患者的比例、UAER、MAU的阳性率、高敏C反应蛋白和纤维蛋白原均高于对照组(P<0.01)。随着冠脉病变数量和程度的增加,UAER(分别为12.9mg/L、34.4mg/L、45.1mg/L和60.7mg/L)和MAU的阳性率(分别为9.8%、41.2%、56.3%和68.4%)均进行性升高(P<0.05,P<0.01)。相关分析显示冠脉病变的Gensini评分与UAER呈正相关(r=0.959,P<0.05)。结论非糖尿病的冠心病患者UAER水平升高,UAER与冠脉病变严重程度呈正相关。更多还原

【Abstract】 Objective To investigate the relationship between microalbuminuria and severity of coronary artery pathologies in patients with coronary heart disease(CHD)but without diabetes mellitus.Methods Coronary angiographies were done and urinary albumin excretion rate(UAER)were measured in 172 cases that suspected CHD but without diabetes mellitus.According to the coronary angiographies all cases were divided into:negative control group(n=51)and CHD group(n=121).According to the number of lesion artery all cases were divided into:no vessel pathologies group(n=51),single vessel group(n=51),double vessel group(n=32)and multi-vessel group(n=38).Compared the UAER in different groups.Results CHD group had more male,higher UAER,the positive rate of microalbuminuria,high sensitivity C-reactive protein and fibrinogen compared with negative control group(P<0.01).UAER(12.9,34.4,45.1 and 60.7 mg/L,respectively)and the positive rate of microalbuminuria(9.8%,41.2%,56.3% and 68.4%,respectively)increase in parallel with the of coronary artery pathologies(P<0.05,P<0.01).Correlation analysis shown that the Gensini’s score of coronary artery atherosclerosis was positively correlated with UAER(r=0.959,P<0.05).Conclusion UAER increase in patients with CHD but without diabetes mellitus.UAER was positively correlated with the severity of coronary artery pathologies.更多还原