【摘要】 目的探讨牛磺酸对肾血管性高血压大鼠心肌肥厚、心肌细胞凋亡、一氧化氮(NO)及血管紧张素II(Ang Ⅱ)含量的影响。方法采用两肾一夹(2K1C)型肾血管性高血压大鼠模型。所有大鼠被随机分为3组(每组20只):假手术对照组、高血压对照组、牛磺酸治疗组。于术后第5周开始给予牛磺酸50mg.kg-1.d-1。采用标准尾套法间接检测清醒大鼠血压。给药8周后,大鼠处死,分离其左室心肌以用于检测左室质量/体质量比、心肌细胞凋亡指数(AI)、NO和Ang Ⅱ含量。结果与假手术组大鼠相比,未给药2K1C高血压大鼠血压明显升高,左室质量体质量比、心肌AI和Ang II含量均升高,心肌NO含量降低。应用牛磺酸治疗则明显降低了肾动脉狭窄术后大鼠的血压、左室质量/体质量比、心肌Ai和Ang II含量;同时也升高了2K1C高血压大鼠心肌NO含量。结论长疗程牛磺酸治疗可抑制高血压大鼠心肌肥厚和心肌细胞凋亡发生,其作用机制与药物调控心源性活性物质分泌水平有关。更多还原

【Abstract】 Objective To investigate the effects of Taurine on cardial hypertrophy,myocardial apoptosis,myocardial nitric oxide(NO) and angiotensin Ⅱ content in renovascular hypertensive rats.Methods The renovascular hypertension model was induced in rats by two-kidney-one-clip method.All the rats were randomly divided into three groups(n=20): ⑴the sham-operated control group;⑵the 2K1C renohypertensive control group;⑶the Tau group,the two-kidney-one-clip rats were treated with taurine at a dose of 50mg·kg-1·d-1 from 5th week after renal artery constriction.Indirect blood pressure was measured in conscious rats by the standard tail-cuff methods.After treatment with both drugs for 8 weeks,the rats were killed and the left ventricle was removed to determine the ratio of left ventricle weight to body weight(LVW/BW),myocardial apoptosis,myocardial nitric oxide content and angiotensin Ⅱ level.Results Compared with the sham-operated control group,the untreated 2K1C renohypertensive rats exhibited an increase in blood pressure,LVW/BW,myocardial apoptosis index and angiotensin Ⅱ level,but myocardial NO content in the untreated 2K1C hypertensive rats were decreased.Treatment with taurine significantly inhibited the increase in blood pressure,LVW/BW,myocardial apoptosis index and angiotensin II level,and exhibited higher myocardial NO content.Conclusion Long-term treatment with taurine could reverse myocardial hypertrophy and inhibit myocardial apoptosis in hypertensive rats,which might be related to its modulation of secretion of cardiac endogenous active substances such as NO and Ang Ⅱ.更多还原