【摘要】 目的:观察动脉血压下降至失血性休克及治疗后家兔大脑皮层诱发电位的变化,了解缺血缺氧纠正后神经系统电活动的变化。方法:(1)记录放血前诱发电位及放血后血压50~60 mmHg(6.65~7.98 kPa)时的皮层诱发电位,测量皮层诱发电位潜伏期正波值、负波值的幅度及峰峰值的幅度和时程。(2)给予扩容补液治疗(补充所失血量及等量生理盐水和654-2 1 mg/kg)半小时后血压恢复到80~100 mmHg时,测定皮层诱发电位的潜伏期正波值、负波值的幅度及峰峰值的幅度和时程,并进行组间比较。结果:放血前后与治疗组皮层诱发电位差异均有统计学意义(P<0.05)。结论:实验性动脉血压下降过程中随着血压下降皮层诱发电位正波、负波、峰峰值幅度均呈现下降趋势,其潜伏期、峰峰时程延长;当血压低于70 mmHg(9.31 kPa)进行扩容时,诱发电位不能恢复到放血前的水平。该变化规律为临床对休克的治疗和有效监测提供了实验依据。更多还原

【Abstract】 Objective: To observe cortical evoked potential (CEP) during the artery blood pressure descended and treated in rabbits.To understand the change of evoked potential when hemorrhagic shock was treated.Method:(1) Record the normal wave of evoked potential before exsanguinated.Hemorrhage maked the blood pressure to 50~60 mmHg(6.65～7.98 kPa),and recorded evoked potential.(2) when the blood pressure is 50~60 mmHg.While treated(transfusion of the whole blood that exsanguinated just and the same quantity physiological saline and 654-2 1 mg/kg),wait for half an hour.The blood pressure recovered to 80～100 mmHg(10.64～13.3 kPa),then recorded CEP,used statistical method to analyse.Results: Control group,hemorrhage group and treatment group have differences(P<0.05).Conclusion: With artery blood pressure descended CEP positive wave values,negative wave values,the p-p values were decreasing.But when the blood pressure was low in 70 mmHg(9.31 kPa),then treated it,the evoked potential could not recover as control group′s.The experimental result provided basis to the treatment of hemorrhagic shock and valid monitor.更多还原