【摘要】 目的观察抑毒调平液对2型糖尿病合并慢性乙肝患者T辅助(Th)细胞因子的影响。方法50例2型糖尿病合并慢性乙型肝炎(中度)患者按随机双盲原则分为治疗组、对照组(每组25例)。两组分别口服抑毒调平液或安慰剂。收集治疗前、治疗后、停药时及停药3个月末空腹血清标本,检测细胞因子白细胞介素-4、干扰素-γ水平。另选30例年龄、性别与治疗组、对照组无明显差异的健康人作正常组。结果治疗前治疗组、对照组患者血清IFN-γ的水平及IFN-γ/IL-4明显低于正常人(p<0.05),IL-4的含量明显高于正常人(p<0.05),治疗组与对照组患者间上述各项指标比较均无显著差异(p>0.05);治疗后、停药时、停药3个月末治疗组IFN-γ、IFN-γ/IL-4的值持续增加(p<0.05),IL-4持续下降(p<0.05),而对照组无明显变化(p>0.05)。结论2型糖尿病合并慢性乙型肝炎(中度)患者其体内Th1/Th2比值失调;抑毒调平液上调血清中IFN-r的含量及IFN-γ/IL-4的比值,下调IL-4的含量,促使Th1/Th2分泌的细胞因子比值恢复平衡,至少维持治疗结束后3个月。更多还原

【Abstract】 Objective To observe the changes of Th1/Th2 cytokines in sera of The chronic patients with hepatitis B (CHB) and type 2 diabetes mellitus (T2DM)who were treated with oral YiDuTiaoPingYe(YDTPY). Methods 50 patients infected with hepatitis B virus (HBV) and T2DM were randomized into two group,receiving either YDTPY (T group,n=25) or Placebo(C group,n=25). In addition,30 health persons were chosen as normal group (N group). Before and after treatment as well as following 3 months,serum IL-4,IFN-γ were measured with enzyme-linked immunosorbent assay(ELISA).Results Before treatment,the serum levels of IFN-γ,IFN-γ/IL-4 were significantly higher in N group than in T group or C group(p<0.05),but IL-4 was significantly lower in N group. There were no significant differences between T group and C group in the parameters mentioned above. Within observing period,the serum levels of IFN-γ,IFN-γ/IL-4 maintained a sustained increase in T group compared with C group(p<0.05). Conclusion YDTPY can regulate up the serum levels of IFN-γ,IFN-γ/IL-4,but IL-4 appeared a contrary trend.更多还原