【摘要】 [目的]探讨尿视黄醇结合蛋白对汞作业者肾脏损害的早期诊断意义。[方法]将85名汞作业者分为汞接触正常组、汞接触超标组,并以无汞接触史的65名健康成人作为对照组。分别进行临床体检并测定尿汞(UHg)、血肌酐(BCr)、尿肌酐(UCr)、血尿素氮(BUN)和尿视黄醇结合蛋白(RBP)的水平。[结果]汞作业者UHg和RBP均显著高于对照组(P﹤0.01),但B-Cr、U-Cr、BUN无统计学意义。[结论]尿视黄醇结合蛋白可作为汞作业工人肾脏损害的早期敏感的诊断指标。更多还原

【Abstract】 [Objective]To study the significance of determination of urinary retinol-binding protein for early diagnosis of renal damage in mercury workers.[Methods]85 mercury workers were divided into two experimental groups:the group with the urinary mercury level higher than the normal value and the group with the urinary mercury level lower than the normal value.65 healthy adults with no mercury exposure history were assigned to the control group.All the subjects had no renal disease history and did not suffer from renal diseases at that time.The results from physical examinations and the measurement of UHg,BCr,UCr,BUN and retinol-binding protein in all groups were analyzed.[Results]The levels of UHg and retinol-binding protein were significantly higher in experimental groups than in the control group(P﹤0.01);however,there were no significant differences in the levels of BCr,UCr and BUN between the experimental group and the control group.[Conclusions]The level of retinol-binding protein can be used as a sensitive indicator for detecting early renal damage caused by mercury.更多还原