【摘要】 目的评价科博肽与盐酸曲马多(TMD)、双氯芬酸钠(SD)及盐酸奈福泮(NFP)在药效、急性毒性方面的相互作用。方法测定科博肽与三种药物单用或配伍时对小鼠扭体的抑制作用;测定单用和配伍时对小鼠的急性毒性。结果科博肽与TMD,SD及NFP配伍后,对小鼠扭体的抑制作用增强(Q均>1.15);与TMD配伍后毒性增强(Q=3.57>1.15),与SD或NFP配伍后毒性降低(Q<0.85)。结论科博肽与TMD、SD、NFP具有药效协同作用;与TMD有毒性增强作用,与SD、NFP有毒性拮抗作用。更多还原

【Abstract】 OBJECTIVE To study the analgesic effect and acute toxicity of Cobratide(CT),Tramadol(TMD),Sodium Diclofenac(SD),Nefopam Hydrochloride(NFP) used singly or used with CT.METHODS The analgesic effect of the medcines were screened by writhing-response in mouse;the acute toxicity to mice of TMD,SD and NFP used singly or used with CT respectively were also estimated. RESULTS The inhibitory effect of Cobratide on the writhing response in mice induced by acetic acid in 1 h were strengthened when used with TMD,SD or NFP respectively;its acute toxicity against mice was increased when used together with TMD,and descended when used together with SD or NFP respectively.CONCLUSION There were synergic efficacy in analgesia between Cobratide and TMD or SD,NFP respectively,there were synergic efficacy between Cobratide and TMD and counteract efficacy between Cobratide and SD or NFP in acute toxicity against mouse.更多还原