【摘要】 目的:观察文拉法辛合并小剂量利培酮对难治性抑郁症患者的疗效及生活质量的影响。方法:选择2003-01/2005-12在佛山市顺德区伍仲珮纪念医院住院及门诊患者100例,符合中国精神障碍分类与诊断标准第3版(CCMD-3)的抑郁症诊断标准,随机分为两组:①实验组(n=50):应用文拉法辛合并利培酮进行治疗,男26例,女24例。②对照组(n=50):单用文拉法辛进行治疗,男24例,女26例。疗程均为6周。采用Hamilton抑郁量表和副反应量表评定临床疗效及不良反应,用世界卫生组织生存质量评定量表评定生活质量。结果:难治性抑郁症患者100例全部进入结果分析。①治疗第2,4,6周末,实验组Hamilton抑郁量表评分均明显低于对照组(P<0.05～0.01),而Hamilton抑郁量表减分率均明显高于对照组(P<0.05～0.01)。②实验组总有效率为64%(32/50),明显高于对照组[40%(20/50),P<0.05]。③两组不良反应均较轻微,大多出现在治疗早期,经过对症治疗逐渐缓解。④治疗后,实验组世界卫生组织生存质量评定量表在心理、生理、独立性和社会关系领域的评分均高于对照组(P<0.05～0.01)。结论:文拉法辛合并小剂量利培酮治疗难治性抑郁症的疗效优于单用文拉法辛,安全性较好,且对生活质量的改善优于单用文拉法辛。更多还原

【Abstract】 AIM: To explore the effects of venlafaxine combined with low-dose risperidone on the curative effect and quality of life in treatment-resistant depression patients. METHODS: 100 patients were enrolled from Hospitalization Department and Out-patient Clinic of Shunde Wuzhongpei Memorial Hospital from January 2003 to December 2005. The depression diagnosis met the third edition of the Chinese classification and diagnostic criteria of mental disorders. All subjects were randomly assigned into two groups, experimental group (n =50) and control group (n =50). Subjects (26 males and 24 females) in the experimental group received venlafaxine combined with risperidone. Subjects (24 males and 26 females) in the control group were treated with only venlafaxine. The duration of treatment was 6 weeks. Clinical curative effect and adverse reaction were evaluated with Hamilton depression scale (HAMD) and treatment emergent symptoms scale (TESS). Quality of life was evaluated with World Health Organization Quality of Life questionnaire (WHOQOL-100). RESULTS: 100 treatment-resistant depression patients were involved in the result analysis. ①The scores of HAMD in the experimental group were significantly lower than the control group at weeks 2, 4 and 6 (P < 0.05-0.01). The reduction rate of HAMD was obviously higher in the experimental group than the control group (P < 0.05-0.01). ②The total effective rate of experimental group was 64% (32/50), and significantly higher than the control group [40%(20/50),P < 0.05]. ③The side reaction was mild in the two groups and most occurred in initial treatment period, and remitted after symptomatic treatment. ④Scores of WHOQOL-100 in psychology, physiology, independence and social relationship in the experimental group were higher than those in the control group after treatment(P < 0.05-0.01). CONCLUSION: The curative effect is better with venlafaxine combined with low-dose risperidone than venlafaxine alone. Venlafaxine is safe. Quality of life is ameliorated significantly with their combination than venlafaxine alone.更多还原