【摘要】 目的:观察低血糖指数的膳食对2型糖尿病患者氧化应激状态的影响。方法:2004-10/11在上海市静安区二个社区卫生服务中心招募受试者,经医生明确诊断为2型糖尿病、病程超过6个月,体质量指数≥24kg/m2的老年糖尿病志愿者43名,受试者对试验知情同意。采用随机交叉试验随机分配至低血糖指数饮食组和高血糖指数饮食组,每种膳食分别连续使用4周,间隔洗脱期4周,比较试验前后患者超氧化物歧化酶、脂质过氧化产物丙二醛和谷胱甘肽过氧化物酶含量的变化。结果:受试者依从性好,除1人因试验期间发现肿瘤而退出试验,42名志愿者按设计要求完成试验。膳食干预后低血糖指数饮食组和高血糖指数饮食组的超氧化物歧化酶活力分别升高了15.68%和21.33%,丙二醛水平分别下降23.94%和21.55%,谷胱甘肽过氧化物酶活力分别升高了15.74%和17.09%;干预后低血糖指数饮食组丙二醛下降水平与高血糖指数饮食组比较差异有显著性意义(P<0.05),而超氧化物歧化酶和谷胱甘肽过氧化物酶活性两组间差异无显著性意义(P>0.05)。结论:在控制总能量的基础上给予平衡膳食能够改善其氧化应激水平,采用低血糖指数食物有助于氧化应激水平的改善。更多还原

【Abstract】 AIM: To explore the change of oxidative stress by low glycemic index (GI) dietary intervention on the overweight patients with type 2 diabetes. METHODS: From October to November in 2004, forty-three subjects with type 2 diabetes for over 6 months were recruited from two Community Health Service Centers of Jingan District in Shanghai. Informed consents were obtained from all the subjects, and their body mass index was no less than 24 kg/m2. They were randomly allocated to a low-GI diet group (LGI) and high-GI diet group (HGI) for two 4-week periods with a 4-week washout period between treatment diets. The changes of superoxide dismutase (SOD), malonic dialdehyde (MDA) and glutathione peroxidase (GSH-PX) were compared before and after the trial. RESULTS: All the subjects were compliant and 42 of them completed the test, whereas one was lost due to tumor appearance. SOD increased 15.68% and 21.33% in LGI and HGI groups, GSH-PX increased 15.74% and 17.09%, and MDA decreased 23.94% and 21.55% respectively. A significant reduction of MDA was observed in LGI group compared with HGI group (P < 0.05). There was no significant difference for SOD and GSH-PX between two groups after the trial (P > 0.05). CONCLUSION: A balance dietary on the basis of controlling total energy intake is benefit for ameliorating oxidative stress. LGI diet may help to improve the oxidative stress in patients with type 2 diabetes.更多还原