【摘要】 以4(5)-3-吡啶基-咪唑为原料,经NaOH去质子成盐、烷基化、肼解制得4-[4-(3-吡啶基)-1H-咪唑基]-1-丁胺,在优化条件下总产率为66%,纯度为97%。克服了原有工艺反应条件苛刻,使用危险试剂等缺点。对碱的浓度,反应溶剂和反应温度等因素进行了探讨研究。更多还原

【Abstract】 4-[4-(3-Pyridinyl)-1H-imidazol-1-yl]-1-butanamine was synthesized from 4(5)-(3-pyridyl) imidazole by deprotonationin in solution of NaOH,alkylation,and hydrazinolysis with an overall yield of 70%,and the purity was 97%.The modified process overcame the disadvantages of harsh and dangerous reaction condition.Influences of the concentration of NaOH,reaction temperature and solvent on yield of product were discussed.更多还原