【摘要】 目的以聚乳酸为载体用溶剂挥发法制得阿司匹林聚乳酸微球。方法选择不同的乳化剂,正交设计实验。以微球包埋率、载药量、表面形态、体外释放为指标优化微球的制备工艺。结果与结论按优化条件制得的微球粒径5～22μm,占80%以上。微球包埋率39.5%,载药量7.25%,体外释药50%需70h。更多还原

【Abstract】 Objective Polylactic acid enveloped aspirin microspheres were prepared by solvent evaporation method.Method The orthogonal test of 3 factors and 3 levels was applied to optimize the preparation procedure.The particle appearance,drug content,and rate of encapsulation were used to evaluate the preparation procedure.Results and Conclusion Microspheres in the range of 5~22 μm were obtained.The drug content was 7.25% and encap sulated rate was 39.5%,and t1/2(in vitro) was 70 h.The results showed the microspheres prepared dy the method had obviously release effect.更多还原