【摘要】 目的:探讨磁共振质子波谱(1HMRS)在儿童癫中的应用。方法:对24例颞叶癫及额叶癫患儿进行1HMRS采集。测定N-乙酰天门冬氨酸(NAA)、肌酸(Cr)、胆碱复合物(Cho)、乳酸(Lac)、谷氨酸及谷氨酰胺(Glu及Gln)、r-氨基丁酸(GABA)等代谢产物,并以15例非颅内病变患儿作为对照。结果:癫组病侧与癫组对侧和对照组NAA/(Cho+Cr)比较,差异有显著性(P<0.01),癫组病侧与癫组对侧和对照组NAA/Cho比较,差异亦有显著性(P<0.01)。结论:1HMRS可无创探测小儿癫癎致癫灶内神经元受损及功能异常的代谢生化改变,有助于小儿癫的定位诊断。更多还原

【Abstract】 Objective:To explore the application of magnetic resonance spectroscopy (1HMRS) in the diagnosis of pediatric epilepsy. Methods: 1HMRS were performed in 24 children with temporal lobe epilepsy (TLE) and frontal lobe epilepsy, 15 children without intracranial disease were used as controls. The concentration of N-acetylaspartate(NAA), Creatine (Cr), Choline-containing (Cho), glutamate and glutamime (Glu/Gln) and lactate (Lac) were measured in all epilepsy and controls. Results: The concentration of NAA and ratio of NAA/(cho/cr) in epileptogenic foci were significantly lower than that of sites on the opposite and control group (P<0.01). Conclusion: 1HMRS can detect the neuron injury and changes of cerebral metabolism in pediatric epilepsy.更多还原