【摘要】 目的观察束缚制动对大鼠体重、行为和肿瘤坏死因子(TNF-α)水平的影响。方法大鼠随机分为6组:对照组、束缚组、2.5%枸杞组、2.5%枸杞+束缚组、5.0%枸杞组和5.0%枸杞+束缚组。采用连续束缚制动21天的方法处理大鼠,将宁夏枸杞干果浸泡后榨成汁以喂饲的方式让实验大鼠自由饮用。结果(1)束缚组大鼠血清皮质醇升高,体重增长缓慢,行为活动减少,血清TNF-α降低,与对照组相比,以上指标差异均有显著性(P<0.05)。(2)2.5%枸杞+束缚组和5.0%枸杞+束缚组两组大鼠血清皮质醇含量降低,行为活动、体重增长明显增加,血清TNF-α含量明显升高,与束缚组相比,均有显著性差异(P<0.05)。结论宁夏枸杞对束缚制动大鼠血清皮质醇、体重、行为及血清TNF-α的变化可能具有良好的调节作用。更多还原

【Abstract】 Objective To explore the effects of Lycium barbarum (L) on the behavior and body weight and TNF-α level of rat treated with binding.Methods Rats were randomly divided into 6 groups:control group,binding group,2.5%L group,5.0 %L group, 2.5%L plus binding group, 5.0%L plus binding group. Lycium barbarums were pressed into juice,then rats were fed with the dranking water contening juice. Rats were bound to restrict for 21 days.Results (1)The increases of serum-cortisol level and the decreases of body weight and the increases of TNF-α level of rats of binding group in comparision with control groups (P<0.05) (2)Rats body weight gain,movement and TNF-α level in both of 2.5%L plus binding group and 5.0%L plus binding group were more higher than those in binding group(P<0.05).Serum-cortisol level of these two groups were more lower and had statistical significance in comparison with those of binding groups(P<0.05).Conclusion Binding could suppress body weight gain and markedly reduce the activity and TNF-α level of rat. Lycium barbarum could be a good adjustment on the behavior, body weight and TNF-α.更多还原