【摘要】 背景:经幽门螺杆菌(H.pylori)根除治疗,约75%的早期胃黏膜相关淋巴组织(MALT)淋巴瘤患者可获得完全缓解。肿瘤细胞有BCL10核表达和t(11;18)(q21;q21)可能提示胃MALT淋巴瘤对根除治疗无反应。目的:探讨单纯H.pylori根除治疗对国人早期胃MALT淋巴瘤的疗效,以及肿瘤细胞BCL10核表达和t(11;18)(q21;q21)对治疗方案选择的提示作用。方法:收集19例早期胃MALT淋巴瘤患者,以免疫组化方法检测BCL10核表达,以间期荧光原位杂交方法检测t(11;18)(q21;q21)。所有患者均首选H.pylori根除治疗,并行内镜活检病理随访。结果:本组19例早期胃MALT淋巴瘤患者中10例(52.6%)经单纯H.pylori根除治疗获得完全缓解。10例完全缓解者中2例(20.0%)肿瘤细胞BCL10核表达阳性,9例对根除治疗无反应者中7例(77.8%)阳性,阳性率显著高于完全缓解者(P<0.05)。14例患者行t(11;18)(q21;q21)检测,8例完全缓解者均未检出该易位,6例对根除治疗无反应者中3例(50.0%)检出该易位,两组检出率差异无统计学意义(P>0.05)。结论:单纯H.pylori根除治疗可使本组52.6%的早期胃MALT淋巴瘤患者获得完全缓解。胃MALT淋巴瘤肿瘤细胞BCL10核表达与其对根除治疗无反应相关。更多还原

【Abstract】 Studies have shown eradication of Helicobacter pylori (H.pylori) resulted in complete regression of early gastric mucosa-associated lymphoid tissue (MALT) lymphoma in approximately 75% of cases,and BCL10 nuclear expression anti t(11;18)(q21;q21) can predict non-response of gastric MALT lymphoma to H.pylori eradication.Aims:To appraise the efficacy of H.pylori eradication in the treatment of early gastric MALT lymphoma patients in our country,and the predictive value of BCL10 nuclear expression and t(11;18)(q21;q21) in the choice of therapeutic regimens.Methods: Nineteen patients with early gastric MALT lymphoma were studied.BCL10 nuclear expression was assessed by immunohistochemistry,and t(11;18)(q21;q21) by interphase fluorescence in situ hybridization.All patients were initially treated by H.pylori eradication therapy and followed up by endoscopy and biopsy pathology.Results:Of the 19 early gastric MALT lymphoma patients,10 (52.6%) acquired complete regression after eradication of H.pylori.BCL10 nuclear expression was detected in 2 (20.0%) of the 10 patients that achieved complete regression,but in 7 (77.8%) of the 9 patients who showed nn response to eradication therapy (P<0.05).t(11;18)(q21;q21) was tound in 3 patients (50.0%,3/6) that had no response to eradication therapy,but none in 8 complete regression patients (P>0.05).Conclusions:52.6% of patients with early gastric MALT lymphoma recruited in this study can acquire complete regression after H.pylori eradication. BCL10 nuclear expression is likely to be related to non-response of gastric MALT lymphoma to eradication therapy.更多还原