【摘要】 研究了间苯二酚常压羧化法制备2,6-二羟基苯甲酸。分析了Kolbe-Schmitt羧化反应机理,选择了该反应的适宜溶剂。通过正交试验确定了反应的最佳参数。在优化的反应参数(间苯二酚/碳酸钾摩尔比1∶0.5,反应温度155～160℃,反应时间6～7h,溶剂为二甲基乙酰胺)下,2,6-二羟基苯甲酸收率达29.38%。更多还原

【Abstract】 2,6-Dihydroxybenzoic acid was prepared by carboxylation of resorcinol in solvent under under atmospheric pressure was studied.The mechanism of Kolbe-Schmitt carboxylation was analyzed and the sutable solvent for the carboxylation reaction was selected.The optimum process parameters were determined by orthogonal test.Under the optimized parameters,i.e.,resorcinol to potassium carbonate molar ratio of 1∶0.5,reaction temperature of 155℃-160℃,reaction time of 6 hours-7 hours,and dimethyl acetamide as solvent,the yield of 2,6-dihydroxybenzoic acid was up to 29.38%。更多还原