【摘要】 目的通过动物实验研究灵芪蠲肝液对细胞外基质的影响。方法四氯化碳溶液复制肝纤维化模型,取血测定纤维化指标透明质酸(HA)、层粘连蛋白(LN)、Ⅲ型前胶原(p—CⅢ)、Ⅳ型胶原(CⅣ);测定10%肝匀浆中羟脯氨酸(Hyp)含量;并取肝组织做病理检查。结果四氯化碳慢性肝损伤时,灵芪蠲肝液可降低HA,LN,PSⅢ,CⅣ,Hyp,与模型组比较差异有显著性(P<0.05);病理发现能减轻肝脂肪变性、减少纤维组织增生、促进肝细胞再生。结论灵芪蠲肝液能调节肝纤维化细胞外基质代谢,减少细胞外基质沉积,从而减轻肝纤维化。更多还原

【Abstract】 Objective To observe effects of Ling Qijuan Gan Liquor(LQL) on extracellar matrix in rats with hepatic fibrosis.Meth- otis The model of hepatic fibrosis was induced by carbon tetrachloride .The changes of serum fibrosis index hyaluronis acid(HA), laminine(LN),prosollagenⅢ(PCⅢ),collagenⅣ(CIV) and hydxy-proline(Hyp) in liver homogenates were measured.Liver tissues were taken to do pathological examination.Results Compared with model group,LQL could notably reduce HA,LN,PCⅢ,CⅣand Hyp when livers were chronic damaged,the differences were striking(P<0.05).Pathol examination found that LQL could lighten denaturalization of liver fat and reduce hyperblasia of fibrous tissue and accelerate rebirth of liver cell.Conclusion LQL can modu- late the metabolism of ECM and reduce sediment of ECM and then alleviate hepatic fibrosis.更多还原