【摘要】 目的研究依达拉奉治疗脑出血时对丙二醛(MDA)、超氧化物歧化酶(SOD)的影响。方法按照入选标准选择107例患者,随机分为依达拉奉组55例、对照组52例,两组均予以常规治疗,依达拉奉组再予以生理盐水150mL+依达拉奉30 mg,每日2次静脉滴注10 d,后改为每日1次静脉滴注7 d 停用。在治疗前、治疗后第4、7、14、21、30天采静脉血测定 MDA、SOD 浓度,并进行评定。在第31天进行治疗前后 ESS 评定。结果治疗后第4、7、14、21、30天,MDA 较治疗前降低,P<0.01,与对照组比较 P<0.01;SOD 较治疗前升高,P<0.01,与对照组比较 P<0.01。在第30天时,二者处于稳定状态。结论依达拉奉降低 MDA,升高 SOD,清除自由基,保护脑细胞,降低脑出血致残率。更多还原

【Abstract】 Objective To study the influence of Malondialdehyde(MDA) and Superoxide dismutase(SOD) of Edarevone on patients with intracranial hemorrhage(ICH).Methods Within an open trial design,100 subjects with ICH received either 60～30mg(52 subjects)of edaravone via intravenous drip or routine treatment(47 subjects).17 days of administra- tion was follomed by a 30-day observation period and the effects of MDA and SOD was evaluated on the 30th day be- tween serum concentrations of MDA,SOD were detected by venous blood sampling was taken before treatment and on the 4th,7th,14th,21th,28th day after treatment.Results The serum MDA level was raised before treatment and was de- creased on the 4th,Tth,14th,21th,28th day after treatment(P<0.01),and the concentration of SOD was decreased or raised respectively(P<0.01).It was P<0.01 as comparing with control.Conclusion Data from the present study sug- gest that edaravone is safe and may reduce the disablement rate of ICH by reducing MDA level and increasing the concen- tration of SOD,edaravone can protect the cerebral cells by clearing free radical.更多还原