【摘要】 目的探讨胰岛素样生长因子-Ⅱ(IGF-Ⅱ)与2型糖尿病外周神经病变的关系。方法将2005年6月至2006年1月浙江大学医学院附属第一医院内分泌科收治的71例2型糖尿病非外周神经病变患者(A组)、77例2型糖尿病外周神经病变患者(B组)及30名健康对照者(C组)纳入研究,测定3组血清IGF-Ⅱ。A、B组加测静脉空腹血糖、胰岛素等相关临床指标及神经电生理检查。结果B组血清IGF-Ⅱ低于A组和C组,差异有显著性意义(P<0.05),C组和A组间血清IGF-Ⅱ差异无显著性意义(P>0.05);血清IGF-Ⅱ与神经传导速度呈正相关(P<0.05);血清IGF-Ⅱ是2型糖尿病外周神经病变的主要相关因素(P<0.05)。结论2型糖尿病外周神经病变患者血清IGF-Ⅱ明显下降,且IGF-Ⅱ降低与2型糖尿病外周神经病变的发生有关。更多还原

【Abstract】 Objective To evaluate the possible relationship between IGF-Ⅱand peripheral neuropathy in type 2 diabetes.Methods Seventy-one type 2 diabetic patients without peripheral neuropathy(Group A),Seventy-seven patients with peripheral neuropathy(Group B)and thiry healthy subjects(Group C)were recruited.Serum IGF-Ⅱwas determined in all subjects.Other clinical parameters(fasting plasma glucose、fasting plasma insulin,et al)and nerve conduction velocity were determined in Group A and Group B.Results Group B had significantly lower levels of IGF-Ⅱ,compared to GroupA and Ⅲ(P<0.05).No significant difference was found between Group A and C;the levels of serum IGF-Ⅱ were positively correlated with motor nerves conduction velocity and sensory nerves conduction velocity;IGF-Ⅱwas independently related to peripheral neuropathy in type 2 diabetes.Conclusion Decreased IGF-Ⅱ in type 2 diabetic patients with peripheral neuropathy may contribute to the pathogenesis of neuropathy.更多还原