【摘要】 目的:观察紫杉醇联合卡铂经静脉、腹腔联合治疗卵巢癌的疗效及毒副作用。方法:27例卵巢上皮癌患者分为4组:A1组,泰素、卡铂静脉推注(5例);A2组,泰素静脉推注、卡铂腹腔滴注(7例);B1组,紫杉醇、卡铂静脉推注(6例);B2组紫杉醇静脉推注、卡铂腹腔化疗(9例)。观察每次化疗后的毒副作用,完成4个疗程后观察疗效。结果:27例中25例完成4个疗程,2例出现过敏性休克而中止化疗。总有效率A1组60%(3/5);A2组71.4%(5/7);B1组50%(3/6);B2组66.7%(6/9)。毒副反应比较,泰素组与紫杉醇组间及腹腔静脉联合化疗组与静脉化疗组间差异均有显著性(P<0.05)。结论:紫杉醇类与卡铂联合化疗对卵巢癌有一定疗效,腹腔静脉联合化疗毒副作用低于单纯静脉化疗,泰素组心脏毒性低于紫杉醇组。更多还原

【Abstract】 Objective:To evaluate the therapeutic effects and toxicities of intraperitoneal and intravenous chemotherapy of taxol plus cisplatin in advanced ovarian cancer.Methods:Total of 27 cases patients of ovarian epithelial carcinoma were divided to four groups A1 group,taxol plus poldine intravenous chemotherapy(5 cases);A2 group,taxol intravenous chemotherapy and poldine intraperitoneal chemotherapy(7 cases);B1 group,paclitaxel plus poldine intraperitoneal chemotherapy(6 cases);B2 group,paclitaxel intravenous chemotherapy and poldine intraperitoneal chemotherapy(9 cases).The toxicities and the short term effects were observed after four courses of therapy.Results:Among 27 cases 25 patients completed four courses therapy,The overall effective rates,A1 group was 60%(3/5),A2 group 71.4%(5/7),B1 group 50%(3/6),B2 group 66.7%(6/9).For side effects there were significance difference among taxol groups and paclitaxel group,among sigle intravenous chemotherapy and intravenous plus intraperitoneal combination chemotherapy(P<0.05).Conclusion:The chemotherapy plus paclitexal was effective for advanced ovarian cancer and the toxicities of intravenous plus intraperitoneal combination chemotherapy was lower than single intravenous chemotherapy.The heart toxicity of taxol was lower than paclitexal.更多还原