【摘要】 用含不同浓度甘草多糖(GPS)的培养液体外培养小鼠腹腔巨噬细胞,测定GPS对巨噬细胞吞噬能力、能量代谢水平和IL-1、IL-6、IL-12含量的影响。结果表明,添加GPS对巨噬细胞的吞噬能力、能量代谢水平和IL-1、IL-6、IL-12的含量具有显著影响,添加GPS的各组均显著高于空白对照组(p<0.01),在添加浓度为600μg/ml时,测定的结果除了IL-12,其余各指标的测定值基本上高于阳性对照组。表明GPS能激活巨噬细胞,提高其吞噬能力和能量代谢水平,同时可分泌多种的具有杀瘤作用的活性因子。综合各指标的测定值,GPS的添加浓度为600μg/ml。更多还原

【Abstract】 The effects of GPS on the phagocytosis capability, energy metabolism level, IL-1、 IL-6 and IL-12 activity were assayed by adding different concentration of GPS into cultured mouse peritoncal macrophages in vitro. The results showed that the effects of GPS on the phagocytosis capability, energy metabolism level, IL-1, IL-6 and IL-12 activity are significantly higher than those in the control group (p<0.01). Concentration of GPS is 600μg/ml, mensurations of the GPS groups index basically were higher than the masculine control groups except of IL-12. It indicated that GPS can activate macrophages to secrete many kinds of active factors with tumoricidal activiy, and enhance its phagocytosis capability and energy metabolism level. It can conclude that the opitimum adding concentration of GPS is 600μg/ml.更多还原