【摘要】 目的通过分析高血压病人血清、尿Ⅲ型胶原水平与β2-微球蛋白排泄率之间的关系,探讨血、尿Ⅲ型胶原及β2-微球蛋白排泄率测定对高血压肾损害诊断意义。方法用放射免疫分析测定57例高血压病人(高血压组)和57例健康对照者(对照组)血清、尿Ⅲ型胶原水平及尿β2-微球蛋白排泄率并进行比较。结果高血压组血清、尿Ⅲ型胶原及尿β2-微球蛋白排泄率均显著高于对照组,差异有显著性(t=3.78~10.53,P<0.001)。高血压组血清、尿Ⅲ型胶原水平与尿β2-微球蛋白排泄率均呈显著正相关(r=0.31、0.32,P<0.05)。结论血清、尿Ⅲ型胶原与尿β2-微球蛋白排泄率联合检测可能更有助于高血压性肾损害的早期诊断。更多还原

【Abstract】 Objective Investigating the relationship between serum and urine levels of collagen Ⅲ(C-Ⅲ) and the excretion rate of urine β2-microglobulin(β2-MG) in order to evaluate their diagnostic value for renal damage in hypertensive patients.Methods Levels of serum and urine C-Ⅲ as well as the excretion rate of urine β2-MG were detected by radioimmunoassay in 57 patients and 57 healthy adults. Results Serum and urine C-Ⅲ and excretion of urine β2-MG were significantly higher in the patients than those in the healthy adults(t=3.78-10.53,P<0.001).Positive correlation between the excretion of urine β2MG and serum and urine levels of C-Ⅲ was noticed in the patients(r=0.31,0.32;P<0.05). Conclusion Combined detection of serum and urine levels of C-Ⅲ and excretion of urine β2-MG is in favor of early diagnosis of the disease.更多还原