【摘要】 胞外ATP除了能广泛作为神经递质外,还被认为是一种旁分泌或自分泌因子。ATP从男性生殖道中的精子或上皮细胞中释放,在调节各种生殖生理功能中起多种作用。本文综述了ATP调节附睾上皮细胞阴离子分泌的信号通路,阐述了ATP对依赖上皮细胞的输精管平滑肌收缩的调节机制,讨论了ATP在男性生殖道中的功能和作用。更多还原

【Abstract】 In addition to its well established role as a neurotransmitter,extracellular ATP has been considered as a paracrine/autocrine factor,either released from sperm or epithelial cells,in the male reproductive tract and shown to play a versatile role in modulating various reproductive functions.This review summarizes the signal pathways through which ATP induces anion secretion by the epithelia of the epididymis,as well as its epithelium-dependent modulation of smooth muscle contraction of the vas deferens.Finally, the overall role of ATP in coordinating various reproductive events in the male genital tract is discussed.更多还原