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针灸足三里穴对衰老模型小鼠皮肤中MDA、GSH-Px和Hyp的影响

Influence of Point Zusanli Acupuncture and Moxibustion on Dermal MDA,GSH-Px and Hyp in A Mouse Model of Senility

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【作者】 杨春英徐斌孙亦农

【Author】 YANG Chun-ying,XU Bin, SUN Yi-nong.Combined Acupuncture and Medicine Laboratory,Nanjing University of Traditional Chinese Medicine,Jiangsu 210029,China

【机构】 南京中医药大学针药结合实验室南京中医药大学针药结合实验室 江苏210029江苏210029

【摘要】 目的观察了针灸足三里穴对衰老小鼠皮肤组织形态的影响。方法长期颈背部皮下注射D-半乳糖造成小鼠亚急性衰老模型,随机分为针刺组、艾灸组、模型组和空白组,检测皮肤组织中丙二醛(MDA)含量、谷胱甘肽过氧化物酶(GSH-Px)活力、羟脯氨酸(Hyp)含量。结果针灸足三里穴能够使衰老模型小鼠皮肤组织中的MDA含量减少,GSH-Px活力增强,Hyp含量增多。结论针灸足三里穴对小鼠皮肤衰老具有拮抗作用。

【Abstract】 Objective To investigate the influence of point Zusanli(ST 36) acupuncture and moxibustion on dermal histomorphology in senility mice.Methods A mouse model of subacute senility was made by long-term nape subcutaneous injection of D-galactose.The mice were randomly allocated to acupuncture,moxibustion,model and blank control groups.Dermal malondialdehyde (MDA) content,glutathione peroxidase(GSH-Px) activity and hydroxyproline(Hyp) content were measured.Results Point Zusanli acupuncture and moxibustion could decrease dermal MDA content,heighten GSH-Px activity and increase Hyp content in a mouse model of senility.Conclusion Point Zusanli acupuncture and moxibustion has an antagonistic effect on mouse skin senility.

【基金】 江苏省高校国家重点实验室培育点针药结合实验室资助
  • 【文献出处】 上海针灸杂志 ,Shanghai Journal of Acupuncture and Moxibustion , 编辑部邮箱 ,2007年10期
  • 【分类号】R245
  • 【被引频次】18
  • 【下载频次】297
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