【摘要】 目的探讨糖心康对糖尿病性心肌病的治疗作用及其作用机制。方法通过腹腔小剂量多次注射链脲佐菌素(STZ)加高热量饮食建立糖尿病大鼠心肌损伤模型,采用全自动生化分析仪测定空腹血糖、糖化血红蛋白,放免法测定胰岛素含量观察糖心康对糖尿病大鼠糖代谢及胰岛素水平的影响;采用免疫组织化学法观察糖心康对糖尿病大鼠心肌NF-κB表达的影响。结果糖心康有明显降低血糖、糖化血红蛋白及提高胰岛素水平的作用(P<0.05);糖心康对糖尿病大鼠心肌NF-κB的过度表达有显著抑制作用(P<0.01)。结论糖心康对糖尿病性心肌病有显著治疗作用,其作用机制之一是通过抑制心肌NF-κB过度表达实现的。更多还原

【Abstract】 Objective To evaluate the therapeutic effects of Tangxinkang on diabetic cardiomyopathy in rat and discuss its mechanism .Methods The model rats were established by ip STZ and hyper-calorie diet.The glucose metabolism,insulin、myocardium histomorphology and nuclear factor-kappa B (NF-κB)were studied and the therapeutic mechanism in biology of Tangxinkang treating the diabetic myocardial damage were also discussed.Results (1)Tangxinkang has good effects on decreasing glucose and HbAlc in blood and increasing the level of insulin.(2)Tangxinkang has good repairing effect on damaged cardiac muscle and pancrease in histomorphologic change.(3)Tangxinkang has obvious adjustment role on over-expressed NF-κB of diabetic cardiac muscle(P<0.01).Conclusion Tangxinkang has an obvious therapeutic role on diabetic cardiomyopathy through adjusting the over-expressed NF-κB of diabetic cardiac muscle mainly.更多还原