【摘要】 通过小鼠骨髓染色体畸变试验、睾丸染色体畸变试验及鼠伤寒沙门氏菌回复试验考察豆类丝核菌次级代谢产物的遗传毒性与致突变性。结果显示,豆类丝核菌次级代谢产物对小鼠骨髓染色体及睾丸染色体均无致畸变作用;Ames试验结果显示在本次试验的各个浓度下无论是加入活化系统(S-9混合液)还是不加,回变菌落数均未大于自然回变菌落的2倍,而各阳性对照组均显示强烈的诱变作用,表明,本次试验剂量和条件下,豆类丝核菌次级代谢产物未见遗传毒性和致突变作用。更多还原

【Abstract】 The genetoxic and mutagenicity effects of the secondary metabolites of Rhizoctonia leguminicola which contained swainsonine were investigated through bone marrow chromosome aberration test,didymus chromosome aberration test and Ames test.The results showed that there were no significant differences between each test group and negative control in chromosome aberration test.Ames test showed that colony didn’t cause double increase of revertants at all doses in every bacterial strains no matter add the active system S-9 or not.All of positive control exhibit intense mutagenesis.The resultes concluded that the secondary metabolites of Rhizoctonia leguminicola had no genetoxic and mutagenic action.更多还原