【摘要】 目的观察高龄髋关节手术后镇痛与全身炎症反应综合征(SIRS)间的相关性。方法将32例65~90岁髋关节手术患者随机分为M组和E组,术后分别采取肌注镇痛和硬膜外自控镇痛,观察肿瘤坏死因子(TNF-α)、白介素6(IL-6)水平变化,并行视觉模拟评分(VAS)与SIRS评分。结果两组TNF-α和IL-6术后均较术前升高,M组持续到术后24 h达峰值,E组术后24 h水平明显低于M组(P<0.05);E组术后各时间点VAS与SIRS评分均明显低于M组。结论高龄髋关节术后应用硬膜外自控镇痛有效降低疼痛强度同时,显著抑制TNF-α、IL-6等释放,有效防治术后SIRS的发生与发展。更多还原

【Abstract】 [Objective] To study the correlation of systemtic inflammatory response syndrome(SIRS) and ease pain after operation of hip joint among senile patients.[Methods] The 32 cases after hip joint surgery were randomly divided into M and E group,postopratively patient controlled extradural analgesia and intramuscular analgesia respectively.The changes of blood serum TNF-α,IL-6 level were measured according to visual analogy score(VAS) and SIRS scale.[Results] A rise in the levels of TNF-α and IL-6 in two groups postoperatively was observed,but there were significant difference in the levels of TNF-α and IL-6 in two groups (P<0.05).The scores of VAS and SIRS were also lower in group E all the time(P<0.05,or P<0.01).[Conclusion] Patient controlled extradural analgesia could inhibit the release of cytokines as TNF-α and IL-6 etc and decrease the occurrence of complications such as SIRS.更多还原