【摘要】 目的探讨蛴螬提取物抗肿瘤作用及其作用机制。方法采用寇氏(Korbor)法计算小鼠急性经口LD50及其95%可信限;用蛴螬提取物灌胃观察其对S180荷瘤小鼠肿瘤的抑制作用,并采用比色法测定S180荷瘤小鼠血清超氧化物歧化酶(SOD)活力和丙二醛(MDA)含量。结果①蛴螬提取物的小鼠急性经口LD50及其95%可信限为48.73(46.43~51.14)g/kg;②蛴螬提取物小、中、大剂量组对小鼠移植性肉瘤S180实体瘤的抑瘤率分别为18.64%、39.47%、53.24%;③经过蛴螬提取物治疗后,荷瘤小鼠血清MDA较模型组明显下降,而SOD活性则显著增加(P<0.01)。结论蛴螬提取物属低毒中药,具有抗氧化作用,可能是其抗肿瘤机制之一;蛴螬提取物在体内具有抑制小鼠移植性S180肉瘤生长的作用。更多还原

【Abstract】 [Objective] To investigate the anti-tumor action and the mechanism of the grub extract.[Methods] Korbor method was used to calculate mice acute oral LD50 values(with their 95% confident limits).The grub extract was administered orally to mice,and tumor inhibition action on S180 sarcoma-bearing mice was observed.Superoxide dismutase (SOD) and malondialdehyde(MDA) were detected by colorimetry.[Results] ①Mice acute oral LD50 value(with their 95% confident limits) of the grub extract was 48.73(46.45-51.12) g/kg.②In the group of low,middle and high dosage,the tumor inhibition rates on mice-bearing S180 were 18.64%,39.47% and 53.24% respectively.③The activity of SOD was higher and the content of MDA was lower in the grub extract treated group than those in control group and approach to the levels of control group(P<0.01).[Conclusion] The grub extract belongs to low toxicity Chinese medicine.The grub extract has significantly anti-tumor effect,the inhibition is probably realized by antioxidant effect.更多还原