【摘要】 目的探讨肿瘤坏死因子-α(TNF-α)和白细胞介素-6(IL-6)基因单核苷酸多态性(SNP)与乙型肝炎病毒(HBV)感染的关系。方法采用基因芯片技术检测150例HBV感染患者(病例组)和不相关联的100例急性乙型肝炎病毒感染自行恢复后对照人群(对照组)中TNF-α-238G/A,-308G/A和IL-6-597G/A,-174G/C,-572G/C位点SNP。结果TNF-α-308GG基因型和G等位基因频率,病例组明显高于对照组(P<0.01,相对危险度[OR]=6.71及P<0.01,OR=2.22);TNF-308AA基因型与抗病毒治疗具有协同作用(P<0.05,OR=2.91)。未见IL-6和TNF-α其他位点的SNP与病例组有任何相关性。结论TNF-308GG基因型及其等位基因G与乙型肝炎病毒感染易感性相关,而TNF-308AA基因型则与抗病毒治疗具有协同抗病毒作用。更多还原

【Abstract】 Objective To investigate relationships between the single nucleotide polymorphisms(SNPs)of tumor necrosis factor-α(TNFα)or interleukin-6(IL-6)promoter genes and susceptibility to patients with chronic hepatitis B(HB)in the Jinan area.Methods The SNPs of the TNF-α(-238G/A and-308G/A)and IL-6(-597G/A,-174G/C and-572G/C)were determined by gene chips in 150 patients infected with hepatitis B virus(HBV)and 100 unrelated healthy controls of self-limited HBV infection.Result Frequencies of the TNF-α-308GG genotype and G allele in patients with HBV infection were significantly higher than those in healthy controls(P<0.01,OR=6.71,and P<0.01,OR=2.22,respectively).The TNF-308AA genotype had a cooperative effect on antiviral therapy(P<0.05,OR=2.91).No association was found between any of the other polymorphisms and patients with HBV infection.Conclusion The TNF-α-308GG genotype and G allele are significantly related to patients with HBV infection,and the TNF-308AA genotype is associated with the response to antiviral therapy.更多还原