【摘要】 目的研究葡萄籽提取物对人体抗氧化能力的影响。方法选年龄在45~65岁的健康志愿者100人,根据血清超氧化物歧化酶(superoxide dismutase,SOD)、谷胱甘肽过氧化物酶(glutathione peroxidase,GSH-Px)活性和丙二醛(maleic dialdehyde,MDA)含量,随机分为试食组和对照组,每组50人,试食组受试者每天口服葡萄籽提取物软胶囊1 g,连续用3个月,对照组不服药。试验前后每人测一次血清中SOD、GSH-Px、MDA三项指标。结果试验后试食组血清SOD、GSH-PX显著高于对照组(P均<0.05),试食组血清MDA含量显著低于对照组(P<0.01);且试食组试验前后自身比较三项指标亦有统计学差异(P均<0.01)。结论葡萄籽提取物具有明显的体内抗氧化活性。更多还原

【Abstract】 Objective To study the anti-oxidative effect of grape seed extract(GSE) in the human body.Methods One hundred healthy volunteers aged from 45 to 65 were randomly divided into two groups: the control group and the GSE-treated group based on the SOD,GSH-Px and MDA levels in the serum.The GSE capsule was administered to the GSE-treated group 1 g/d orally for 3 months,while no drugs were administered to the control group.The SOD,GSH-Px and MDA levels in the serum were determined both prior to and after the experiment.Results The SOD and GSH-Px levels were significant higher in the GSE-treated group than in the control group(P<0.05),while the MDA level was significantly lower in the GSE-treated group than in the control group(P<0.01).Moreover,there were significant differences in the three indexes in the GSE-treated group between prior to and after the experiment(P<0.01).Conclusion GSE has a significant anti-oxidative effect in vivo.更多还原