【摘要】 目的观察核苷类似物序贯疗法对慢性HBV携带者的疗效。方法采用序贯疗法,口服拉米夫啶(LVD),6月后联合服用阿德福韦酯(ADV),2月后停服LVD,续用ADV12月,总疗程18月;用RT-PCR法测定患者抗病毒治疗前后血HBVDNA含量。结果经LVD、ADV序贯治疗后,所有慢性HBV携带者的血清HBV DNA水平都经历一段短暂下降过程之后,大多数又逐渐恢复到治疗前水平,只有少数(20%)慢性HBV携带者疗程结束后6月,其HBV DNA仍是低于检测下限值。结论核苷类似物序贯疗法可使少数(20%)慢性HBV携带者的血清HBV-DNA转阴。更多还原

【Abstract】 Objective To observe the effect of sequential use of nucleosides on chronic HBV carriers.Methods Sequential thereapy was used,lamivudine(LVD)was firstly given to the patients,six months later LVD combined with adfovir dipivoxil(ADV)was used,then two months later LVD was no longer used and ADV was continued for 12 months with a total course of 18 months.The contents of HBVDNA in the patients before and after treatment was determined with RT—PCR.Results The level of HBVDNA in serum of all chronic HBV carriers was gradually returned to the levels before treatment after short period of drop.The level of HBVDNA was still kept at the lower limit 6 months after completion of the course in 20% of the chronic HBV carriers.Conclusion The serum HBVDNA become negative in 20% of chronic HBV carriers by using sequential therapy with nuceosides.更多还原