【摘要】 乳腺癌是女性最常见的恶性肿瘤之一,局部晚期乳腺癌(LABC)的治疗是世界范围内的临床难题,影响着乳腺癌总体生存率的提高。LABC的涵盖范围伴随着TNM分期系统的修订而不断变化。已有的研究证明,新辅助化疗后可以进行保留乳房手术(BCT),但要严格掌握适应证,保留乳房手术的指征已逐渐取得共识。开始治疗之前准确记录或定位肿瘤,要保证足够的阴性切缘。对于腋窝淋巴结手术问题仍有争议,多数主张常规进行清除手术。预后上不差于早期乳腺癌作保留乳房手术后的局部复发率。更多还原

【Abstract】 Breast cancer is one of the most common malignant tumors in women. The treatment of locally advanced breast cancer (LABC) is a tough clinical problem in the world and hampering to improve the overall survival of breast cancer patients. Followed the revises of TNM staging system for breast cancer, the classification of LABC has been kept alternating continuously for decades. Previously finished studies presented that breast conservation therapy (BCT) may be carried out in locally advanced breast cancer patients after neoadjuvant chemotherapy, but the indication should be controlled strictly. The indication of BCT has been made an agreement gradually. BCT should record and mark the preoperative edge and position of tumors exactly, and ensure adequate negative cutting edges. Inregard to axillary lymph node dissection, the argument still remains by now, and most of authors suggested to complete axillary clearance conventionally. The local recurrence of breast conservation therapy in LABC patients is not worse than that in early breast cancer patients.更多还原