【摘要】 目的:探讨γ探测仪结合核素淋巴显像检测皮肤恶性黑色素瘤前哨淋巴结(sentinel lymph node,SLN)的准确性及其临床价值。方法:27例皮肤恶性黑色素瘤患者,术前1~2h在肿瘤病灶周围3、6、9、12点钟位置皮下注射显像剂99mTc-硫胶体,用γ探测仪结合核素淋巴显像定位探测SLN,术中切除SLN,随后行淋巴结清除术。对阴性SLN进行连续切片,行S-100和HMB-45免疫组化分析。结果:26例患者检出SLN,检出率为96.2%,SLN阳性为7例,阳性率为26.9%,准确率为100%。结论:γ探测仪结合核素淋巴显像检测恶性黑色素瘤的SLN是准确的,能够反应区域淋巴结转移状态,能很好的协助SLN的定位。更多还原

【Abstract】 OBJECTIVE:To evaluate the accuracy and clinical value of gamma probe and lymphoscintigraphy in sentinel lymph node identification for cutaneous elanoma. METHODS: 99mTc-labeled sulfur colloid was injected in 27 patients with cutaneous melanoma about 1-2 hours before the operation. The sentinel lymph nodes were identified by lymphoscintigrphy and gamma probe, followed by resection and regional lymphadenectomy. Serial section and immunohistochemistry staining with antibodies to S-100 and HMB-45 were peformed in all negtive sentinel lymph nodes. RESULTS: Sentinel lymph nodes were identified in 26 patients, with a detection rate of 96.2%. Seven (26.9%) of twenty-six melanomas were found to have positive sentinel lymph nodes. The accuracy rate of sentinel lymph node was 100%. CONCLUSION: Gamma probe and lymphoscintigraphy aided sentinel lymph node biopsy can predict regional node status.更多还原