【摘要】 为观察多西紫杉醇联合顺铂(DDP)两种方案治疗晚期非小细胞肺癌(NSCLC)的疗效及毒副反应,将79例晚期NSCLC患者随机分为3周剂量组和每周剂量组。3周剂量组:多西紫杉醇75mg/m2,d1;DDP80mg/m2。分3～5d静脉滴入,21d为1个周期。每周剂量组:多西紫杉醇35mg/m2,d1、d8、d15;DDP80mg/m2,分3～5d静脉滴入,28d为1个周期。每例患者至少应用2个周期。结果:3周剂量组和每周剂量组有效率分别为36.8%和34.1%(χ2=0.063,P=0.802),初治患者有效率分别为45.5%和46.2%,复治患者有效率分别为33.3%和28.6%。常见的毒副反应为骨髓抑制及消化道反应,反应程度以Ⅰ～Ⅲ度为主。初步研究结果提示,多西紫杉醇联合DDP治疗晚期NSCLC两种方案疗效相当,毒副反应每周剂量组较3周剂量组轻微。更多还原

【Abstract】 To objective of this study was to investigate the response and toxicity of DOC and DDP in the treatment of advanced non-small cell lung cancer through three-week regimen and weekly regimen.Three-week regimen:Docetaxel 75 mg/m2 per three weeks was given through intravenous dripping,and cisplatin 80 mg/m2 was given through intravenous dripping for 3 or 5 days.The courses were repeated every 21 d for 2 cycles.Weekly regimen:Docetaxel 35 mg/m2 per week was given through intravenous dripping for 3 weeks,and cisplatin 80 mg/m2 was given through intravenous dripping for 3 or 5 days.The courses were repeated every 28 d for 2 cycles.The response rates of the two regimens were obtained in 36.8% and 34.1%,respectively(χ2=0.063,P=0.802).The response rates of first treatment patients were 45.5% and 46.2%.The response rates of retreatment patients were 33.3% and 28.6%.The main toxicities were myelosuppression and digestive system reaction.In conclusion,the effect of the combination chemotherapy of docetaxel and cisplatin through three week regimen and weekly regimen is consistant.Compaired with three week regimen the decrease of WBC of weekly regimen is low in the treatment of advanced non-small cell lung cancer.更多还原