【摘要】 目的研究乙型肝炎免疫球蛋白(HBIG)和泰来肽(TLT)对感染HBV孕妇血清和初乳HBV-DNA含量的影响。方法选择感染HBV的孕妇(HBsAg、HBeAg、HBV-DNA阳性)162例,分为:治疗Ⅰ组50例,于妊娠20周起肌肉注射HBIG200IU,1次/月,至分娩为止;治疗Ⅱ组40例,在治疗Ⅰ组肌注HBIG的基础上自妊娠28周起肌注TLT2ml,1次/d,至分娩为止;对照组72例,自然观察。分别采集孕妇治疗前、后血清和初乳,检测HBV-DNA含量。结果治疗前3组孕妇血清HBV-DNA含量间差别无显著性意义(P>0.05);治疗后3组孕妇血清和初乳HBV-DNA含量间差别均有显著性意义(P<0.05),而治疗后治疗Ⅰ、Ⅱ组孕妇血清和初乳HBV-DNA含量间差异均无显著性意义(P>0.05)。结论HBIG联合TLT与单独使用HBIG对孕妇血清和初乳中HBV-DNA的含量无差别。更多还原

【Abstract】 Objective To study the effect of HBIG combined with Tailaitai(TLT)on levels of HBV-DNA of colostrum and HBV-infected pregnancy serum.Methods 72 gravidas were selected as a control group,who were observed naturally;162 were divided into two groups:Group I(50 gravidas),who were given intramuscular(IM)injections of HBIG(200 IU,once a month)from the 20th week to delivery time;Group Ⅱ(40 gravidas),who were given additional IM of TLT(once daily,from the 28th week to delivery time)besides HBIG.We examined the levels of HBV-DNA of serum and colostrum,which were collected respectively before and after the treatment.Results There was no significant difference in levels of serum HBV-DNA among the three groups before treatment(P>0.05);Significant difference was observed in levels of HBV-DNA of serum and colostrum among the three groups after treatment(P<0.05);There was no significant difference in levels of HBV-DNA of serum and colostrum between Group I and Group Ⅱ after treatment(P>0.05).Conclusion The treatment with HBIG combined with TLT has the same effect as that with only HBIG on HBV-DNA levels of pregnancy serum and colostrum.更多还原