【摘要】 线粒体在细胞能量代谢,氧自由基生成和细胞凋亡中发挥重要作用。肿瘤细胞的线粒体功能障碍是其重要的特征之一。正常细胞线粒体在分子、生化、代谢和遗传水平上明显区别于癌细胞。线粒体DNA(mi-tochondria DNA,mtDNA)是核外唯一的遗传物质,线粒体基因组与肿瘤的关系日益受到关注。mtDNA编码参与氧化磷酸化和ATP生成所需多肽,由于其独特的生物学环境和结构特性,与核基因组相比,mtDNA更容易发生氧化损伤和突变。已经在很多肿瘤及细胞系中发现了mtDNA结构和功能的变化。肿瘤细胞mtDNA的核内整合可能是导致细胞癌变的重要因素,而突变mtDNA的检测可望成为肿瘤的非侵入性诊断的有效分子标记。更多还原

【Abstract】 Mitochondria plays an important role in cellular energy metabolism,free radical generation and apoptosis.Mitochondrial dysfunction is one of the most profound features of cancer cells.Several distinct differences between the mitochondria of normal cells and cancer cells have been observed at the molecular,biochemical,metabolic and genetic levels.mtDNA(mitochondrial DNA) is the only extra-nuclear gene.Studies have shown that mitochondrial genome has relationship with carcino genesis and its development,which has been brought into the limelight for a broader audience.mtDNA encodes the polypeptides required for oxidative phosphorylation and synthesis of ATP.Because of its special biological and structural characters,mtDNA is more vulnerable to oxidative damage and undergoes a higher rate of mutation than nDNA.Various tumors contained mtDNA mutations that were not present in healthy tissues from the same individuals.The mechanism of nDNA mutagenesis involving the integration of mtDNA fragments may plays an important role in carcinogenesis.Furthermore,mtDNA mutations may become a potential effective molecular marker in view of the role on noninvasive detection of carcinoma.更多还原