【摘要】 根据单味中药的药理作用及药味增减理论,对前期研究的抗氟复方当归散基础方加以改进,分别拟定出抗氟复方当归散Ⅰ、Ⅱ、Ⅲ和Ⅳ,并分别灌服给予氟中毒大鼠,以观察它们对氟中毒大鼠氟排泄和组织氟含量的影响。阴性对照组自由饮自来水,其余各组自由饮含氟100mg/L的自来水,并按0.1g/kg给予各复方当归散。在试验期,观察各组大鼠氟斑牙发生情况,跟踪检测尿氟和粪氟含量。试验结束时,测定各组大鼠骨、血浆、肝和肾氟含量。结果表明,阳性对照组已成功复制出慢性氟中毒模型;在各给药组中,给予抗氟复方当归散Ⅲ组的氟排泄量较多,且明显减少组织氟含量,具有相对较强的排氟效应。更多还原

【Abstract】 Based on Chinese medicine theory and single herb’s pharmacological action,the basic anti-fluorine compound DANGGUI powder were improved and four other compound DANGGUI powderⅠ,Ⅱ,Ⅲ and Ⅳ were designed for comparative studying of their anti-fluorine pharmacological effects.All the Wistar rats were assigned to 7 groups,which are negative control group,positive control group and 5 other therapeutic groups,respectively.The negative control group was drunk with normal tap water,the others were drunk with water containing of 100mg/L fluorine.Except the rats in 2 control groups all other rats were administered 5 different kinds of anti-fluorine compound DANGGUI powder simultaneously by per os with dosage of 0.1g/kg,respectively.The dental damage was inspected seriously and the contents of fluorine in urine,dung,plasma,liver,kidney and bone were determined during the experiment.The experimental results showed that all of the anti-fluorine compound DANGGUI powders can obviously alleviate the dental damage and increase the excretion of fluorine from dung and also can reduce the fluorine contents in some tissues.Therefore,the anti-fluorine compound DANGGUI powders have excretive effects on fluorine.更多还原