【摘要】 目的:探讨阿托伐他汀对慢性心力衰竭患者左室射血分数(LVEF),脑利钠肽(BNP)及肿瘤坏死因子(TNF-α)、核转录因子(NF-κB)活性的影响。方法:将血脂正常的慢性心力衰竭患者50例随机分为对照组(25例)和他汀组(25例)。两组均接受常规治疗(利尿剂、ACEI、或洋地黄、β-受体阻滞剂),他汀组再加用阿托伐他汀(20mg/d)治疗,治疗前及治疗后12周均测LVEF、血清BNP、TNF-α、外周血单个核细胞NF-κB活性。结果:BNP、TNF-α、NF-κB活性与心力衰竭严重程度正相关,治疗12周后,两组TNF-α、BNP、NF-κB活性均下降(P<0.05),LVEF升高(P<0.05),且以他汀组变化更明显,与对照组比较差异有统计学意义(P<0.05)。结论:慢性心力衰竭患者在接受常规治疗的同时,加用阿托伐他汀治疗可明显改善LVEF、降低BNP、TNF-α及NF-κB活性。更多还原

【Abstract】 Objective:To investigate the effects of atorvastatin on left ventricular ejection fraction(LVEF),brain natriuretic peptide(BNP),TNF-α,nuclear factor-kappaB(NF-κB)activity in patients with chronic heart failure.Methods:Fifty chronic heart failure patients with normal blood lipids were randomly divided into control group(n=25)and atorvastatin group(n=25).Control group treated with routine therapy,atorvastatin group treated with atorvastatin based on routine therapy for 12 weeks.LVEF,BNP,TNF-α and NF-κB activity in peripheral blood monoeuclear cells(PBMC) were measured 12 weeks before and after treatment.Results:Levels of TNF-α,BNP and NF-κB activity were significantly correlated with severity of cardiac function.Level of TNF-α,BNP and NF-κB activity were decreased after 12 weeks’treatment(P<0.05).LVEF was increased compared with that before treatment in both groups,especially in atorvastatin group(P<0.05).Conclusion:LVEF may be further improved while TNF-α,BNP and NF-κB activity were further decreased in patients with chronic heart failure after treatment with atorvastatin on basis of routine treatment.更多还原