【摘要】 目的研究新生儿呼吸衰竭患儿的撤机过程中,采用有创-无创序贯性通气能提高撤机的成功率。方法将34例新生儿呼吸衰竭患儿随机分成两组,17例患儿接受有创-无创序贯通气治疗为治疗组,17例患儿接受传统脱机治疗为对照组,比较两组的撤机成功率、总用氧时间,并同时观察两组患儿的呼吸暂停及漏斗胸的患病率。结果治疗组与对照组的撤机成功率分别为94.1%和70.6%(P<0.05);总用氧时间分别为(15±6)d和(21±8)d(P<0.05);呼吸暂停的患病率分别为5.9%和23.5%(P<0.05);漏斗胸的患病率分别为0和17.6%(P<0.05)。结论使用有创-无创序贯性通气模式治疗新生儿呼吸衰竭较传统脱机模式更有效,提高了撤机成功率,并降低了并发症的发生率。更多还原

【Abstract】 Objective Many controversial questions remain concerning the best methods for conducting the weaning process from mechanical support and from the endotracheal tube.We aimed to assess whether sequential invasive-noninvasive mechanical ventilation can increase the weaning success rate and improve the outcomes of patients with neonatal respiratory failure(NRF) compared with conventional mechanical ventilation.Methods A prospective randomized trial was conducted at the intensive care unit(ICU) over 2 years included 34 patients with NRF.Thirty-four patients were randomly assigned to therapy group(n=17) and control group(n=17),the therapy group was treated by sequential invasive-noninvasive mechanical ventilation and the control group was treated by conventional weaning mode.The two groups were compared by determing the weaning success rate,time of oxygen requirement and the incidence of apnea and funnalchest.Results The weaning success rate was 94.1% in therapy group versus 70.6% in control group(P<0.05).The time of oxygen requirement was(15±6)days in therapy group versus(21±8)days in control group(P<0.05).The incidence of apnea and funnalchest were 5.9% and 0 in therapy group versus 23.5% and 17.6% in control group(P<0.05).Conclusion Compared with conventional weaning from mechanical ventilation,Sequential invasive-noninvasive mechanical ventilation is more effective in treating patients with NRF.It can increase the weaning success rate and decrease complications of patients.更多还原