【摘要】 目的:探讨T细胞亚群(CD3+、CD4+、CD8+T)在斑秃发病中所起的作用。方法:用流式细胞仪分别检测斑秃患者PBMC中CD3+、CD4+、CD8+T淋巴细胞的表达水平。结果:重型斑秃、轻型斑秃的CD4+T淋巴细胞表达高于正常对照组,且差异有统计学意义;重型斑秃、轻型斑秃的CD8+T淋巴细胞表达亦高于正常对照组,且差异有统计学意义;CD3+T淋巴细胞表达、CD4+/CD8+比值较正常对照升高,差异无统计学意义。结论:提示了由T淋巴细胞介导的斑秃的发病机理,CD8+和CD4+T淋巴细胞在其发病过程中起到重要作用,两者协同作用导致毛囊受损。更多还原

【Abstract】 Objective:To study the relationship between the expression of T lymphocyte subtypes and alopecia areata(AA).Methods:CD4+、CD8+ CD3+ T lymphocytes were sorted out by flow cytometry.Results:The expression of CD4+ and CD8+ lymphocytes in patients with AA was significantly increased than that in controls.The expression of CD3 lymphocytes and the ratio of CD4+/CD8+ in AA were slightly increased compared with controls,but the difference was not significant.Conclusion:The study indicates that AA is a T lymphocyte mediated tissue-restricted autoimmune disease.CD4+ and CD8+ T lymphocytes play an important role in the pathogenesis of AA.更多还原