【摘要】 目的:研究氟比洛芬酯超前镇痛在妇科腹腔镜手术中的应用。方法:60例ASAⅠ～Ⅱ级择期行妇科手术的患者,随机分为三组,每组20例。对照组(C组)麻醉诱导前和术毕患者拔管清醒即刻静脉缓慢注射脂肪乳5mL;超前镇痛组(P组)麻醉诱导前静脉缓慢注射氟比洛芬酯5mL,术毕患者拔管清醒即刻静脉缓慢注射脂肪乳5mL;常规镇痛组(R组)麻醉诱导前静脉缓慢注射脂肪乳5mL,术毕患者拔管清醒即刻静脉缓慢注射氟比洛芬酯5mL。分别记录拔管清醒即刻、1、2、4、6、12、24h的视觉模拟评分法(VAS)的评分;记录24小时追加镇痛药情况;并统计24h内不良反应。结果:术后P组1、2、4、6、12h的VAS评分明显低于C组同时点VAS评分(P<0.05);而P组1、2、4、6h的VAS评分明显低于R组同时点VAS评分(P<0.05)。结论:氟比洛芬酯可安全地用于妇科腹腔镜手术镇痛,而使用超前镇痛可提供更好的术后镇痛效果。更多还原

【Abstract】 Objective: To evaluate the efficacy and safety of flurbiprofen axetil in gynecological patients undergoing laparoscopic surgery. Methods: 60 ASA I orⅡ gynecological patients scheduled for elective laparoscopic surgery were randomly allocated into three groups (n=20 each). Group C (control): fat milk 5 mL were given both before induction and after recovery. Group P (pre-empty): flurbiprofen axetil 5mL was given before induction and fat milk 5 mL was given after recovery. Group R (regular): fat milk 5mL was given before induction and flurbiprofen axetil 5 mL was given after recovery. Additional dosages of analgesics and side effect within 24 hours, VAS at 0, 1, 2, 4, 6, 12, 24 hr were recorded. Results: In group P, the VAS was lower than group C (P < 0.05) at all time point, and lower than group R (P < 0.05) at the former time point (0, 1, 2, 4, 6 h). Conclusion: Pre-empty analgesic with flurbiprofen axetil could provide satisfying analgesic effect in gynecological patients undergoing laparoscopic surgery.更多还原