【摘要】 目的:检测乳腺癌中趋化因子受体CCR7的表达及其临床意义。方法:收集65例根治性切除的乳腺癌标本,用免疫组织化学法检测CCR7的表达,分析CCR7的表达与乳腺癌患者临床病理特征之间的相关性。结果:65例标本中,42例存在CCR7的高表达(64.6%),CCR7的表达与乳腺癌患者的淋巴结转移、TNM分期和肿瘤组织中淋巴细胞的浸润程度密切相关,但与淋巴结转移的数目无关。结论:趋化因子受体CCR7与乳腺癌淋巴结转移密切相关,其在乳腺癌的临床诊治中有参考价值。更多还原

【Abstract】 Objective:To detect the expression and its value of CCR7 in breast cancer. Methods:CCR7 expression was investigated by means of immunohistochemistry in 65 patients with breast cancer who underwent radical mastectomy. The correlation of CCR7 expression and other clinical features was analyzed. Results:CCR7 receptor was expressed in 42 cases (64.6%). The CCR7 expression was significantly associated with lymph node metastasis, stage and lymphocyte infiltration. But the number of metastatic lymph node was not associated with the expression of CCR7. Conclusion:CCR7 receptor plays an important role in the lymph node metastasis in breast cancer, which could be used in the clinical practice of breast cancer.更多还原