【摘要】 目的:观察放疗同步联合NP方案化疗治疗食管癌的疗效。方法::对符合条件的62例食管癌患者,按序列随机分成2组,放疗同步联合NP方案化疗(综合治疗组)30例,于放疗中及放疗后配合"顺铂+盖诺"方案化疗3～4疗程;单纯根治性放疗组(单纯放疗组)32例。结果::综合治疗组与单纯放疗组的近期疗效(CR+PR)分别为83.0%和78.0%(P>0.05),1、2、3年生存率分别为76.6%、55.5%、40.0%和49.0%、31.0%、21.0%,两组比较有显著性差异(P<0.05);综合治疗组1、2、3年无瘤生存率分别为70.2%、43.2%、22.0%,单纯放疗组分别为42.0%、20.5%、18.0%,两组比较有显著差异(P<0.05)。毒副作用发生率综合治疗组(30.0%)高于单纯放疗组(6.3%),(P<0.05)。结论:放疗联合NP方案化疗对中晚期食管癌治疗有较好疗效,可提高生存率。更多还原

【Abstract】 Objective:To evaluate the efficacy of radiotherapy combined with chemotherapy with Cisplatin,Vinorelbine for the advanced stage of esophageal carcinoma.Methods:Sixty-two patients were randomly divided into radiotherapy combined with chemotherapy group(study group,n=30)and pure radiotherapy group(control group,n=32),The study group were re- ceived 3～4 cycles of NP chemotherapy.while the control group were only given radiotherapy.Results:The short-term effect rate of the two group were 83.0% and 78.0%,respectively survival rates of one,two and three years were 76.6%,55.5%,40. 05 and 49.0%,31.0%,21.0%(P<0.05).respectively disease free survival rates of one,two and three years were 70.2%, 43.2%,22.0% and 42.0%,20.5%,18.0%(P<0.05).respectively survival rate and disease free survival rate of study group were higher than control group.The side effect of study group(30.0%)was higher than control group(6.3%)(P<0.05).Con- clusion:Radiotherapy combined with chemotherapy for esophageal carcinoma has synergistic action.更多还原